使用含有乙inylestradiol-norgestimate的药丸可以改善女性的性行为,尽管循环中的雄激素减少:试点研究
Maurizio Guida1, Luciano Quercitelli1, Pasquale De Franciscis2
1University Federico II, Naples, Italy.
概括
这项研究发现,含有乙inyl-estradiol和norgestimate的联合口服避孕药 (COCs) 改善了女性的性欲得分. 尽管丸激素和DHEAS显著下降,但性功能在短期内并没有下降.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 药理学 药理学 是一个学科.
背景情况:
- 联合口服避孕药 (COCs) 广泛用于避孕.
- 对女性性和雄激素水平的COC的影响需要进一步调查.
研究的目的:
- 评估含有乙inyl-estradiol (EE) 和norgestimate (NGM) 的联合口服避孕药 (COC) 对女性性行为的短期影响.
- 评估这种COC对循环中的雄激素水平的影响,特别是 (T) 和脱乙硫酸 (DHEAS).
主要方法:
- 一项为期6个月的研究,涉及36名女性使用单相药丸,EE为35μg,NGM为0.250mg.
- 在治疗前和治疗后测量了麦考伊女性性质问卷 (MFSQ) 和T和DHEAS的血清水平.
主要成果:
- 观察到MFSQ得分的显著改善 (p < 0.0001),不包括阴道滑领域.
- 同时发现血清丸激素 (-4.45%,p < 0.0001) 和DHEAS (-19.41%,p < 0.0001) 的显著下降.
结论:
- 含有COC的乙inyl-estradiol/norgestimate (EE/NGM) 显示对女性性行为产生短期的非有害影响.
- 在使用COC期间,女性的性行为是多因素的,不仅仅取决于雄激素水平.
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