相关实验视频

Updated: Jun 22, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

在免疫能力强的小鼠中模拟人类胃癌

Weihong Zhang^1,2, Shilong Wang², Hui Zhang²

¹Department of Stomatology, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai 200072, China.

Cancer biology & medicine

|June 28, 2024

概括

胃癌 (GC) 研究正在推进,重点关注分子亚型和免疫微环境. 具有免疫能力的小鼠模型对于理解GC病理学和开发新的免疫疗法至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

胃癌 (GC) 是全球癌症死亡的主要原因.
GC表现出显著的异质性,使研究和治疗开发复杂化.
了解GC的分子和环境驱动因素至关重要.

研究的目的:

审查胃癌研究的进展和挑战.
总结用于GC研究的免疫能力较强的小鼠模型.
突出小鼠模型在促进抗瘤免疫力和免疫治疗中的作用.

主要方法:

关于胃癌的当前科学文献的综述.
分子亚型和免疫微环境研究的分析.
临床前免疫能力较强的小鼠模型和有机体培养物的评估.

主要成果:

在了解GC分子亚型和免疫逃避方面取得了重大进展.
开发临床前模型,包括免疫能力强的小鼠,有助于机理学研究.
基因工程小鼠模型显示出免疫疗法研究的前景.

结论:

解决GC异质性是改善诊断和治疗的关键.
具有免疫能力的小鼠模型对于研究GC抗瘤免疫力是无价的.
使用这些模型进行进一步的研究可以加速开发新的胃癌免疫疗法.

关键词:

这就是GEMM.胃癌是什么?胃癌是什么?异质性的异质性具有免疫能力的免疫能力.鼠标模型鼠标模型鼠标模型

更多相关视频

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Published on: July 19, 2019

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

相关概念视频

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...