患有ANCA相关血管炎的患者的肺功能
Johannes Dieterich1, Bernhard Hellmich1, Juliane Mahrhold1
1medius Klinik Kirchheim, Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabetology.
概括
与ANCA相关的血管炎 (AAV) 患者表现出与他们的肺部状况相关的特定肺功能测试变化. 这些变化随着时间的推移而持续,与疾病活动无关.
科学领域:
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 在ANCA相关血管炎 (AAV) 中,肺部表现很常见.
- 关于AAV对肺功能影响的经验数据有限.
- 这项研究调查了肺功能测试 (PFT) 结果在一个大的AAV队列.
研究的目的:
- 为了分析AAV患者的PFT数据.
- 为了将PFT发现与成像和疾病活动相关联.
- 在不同的AAV亚型中识别特定的PFT变化.
主要方法:
- 从147名AAV患者 (2008-2018) 的PFT数据进行了回顾性分析.
- 将PFT结果与人口,疾病和成像特征进行比较.
- 评估随着时间的推移而发生的变化以及与疾病活动的相关性.
主要成果:
- 带有多胞膜炎 (GPA) 的粒状瘤显示FVCex,RV和TLCO的减少.
- 显微多炎 (MPA) 呈现出减少的FVCex,TLC和TLCO.
- 带有多炎 (EGPA) 的乙酸性粒状瘤增加了RAWtot,增加了VR,并降低了TLCO.
- 间歇性肺病 (ILD) 与FVCex,TLC,RV和TLCO的显著下降有关.
- 在初始和随访PFT之间或在活跃和不活跃的疾病状态之间没有发现显著差异.
结论:
- 根据肺部和呼吸道的参与,AAV患者表现出明显的PFT变化.
- 这些PFT变化随着时间的推移而保持稳定.
- 在AAV中PFT发现独立于当前的疾病活动.
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