相关实验视频
Updated: Jun 22, 2025

05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.6K
淋巴细胞甲状腺炎和乳腺甲状腺癌携带突变BRAF之间的关联:系统性审查和元分析
Sumathy Perampalam1,2,3, Katherine Wu4, Matti Gild3,4
1Department of Diabetes and Endocrinology, Canberra Hospital, Garran, Australia.
概括
淋巴细胞性甲状腺炎 (LT) 与BRAF突变的乳头甲状腺癌 (PTC-BRAF) 的患病率较低有关,这种亚型与更差的预后有关. 然而,LT并没有显著影响PTC复发率.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 乳头甲状腺癌 (PTC) 和淋巴细胞甲状腺炎 (LT) 经常同时发生.
- 携带BRAF突变的PTC (PTC-BRAF) 与更糟糕的预后有关.
- 对于LT对PTC预后特征和复发的影响尚不清楚.
研究的目的:
- 为了比较PTC-BRAF在存在和不存在LT的患病率.
- 评估BRAF突变状态与临床病理特征之间的关联.
- 评估LT对PTC预后因素和复发的影响,无论BRAF状态如何.
主要方法:
- 观察性研究的系统审查和元分析.
- 在PubMed,Embase和Web of Science核心集合中进行了搜索 (2010年至2023年6月).
- 从39项研究 (28,143名患者) 中提取了基线特征,临床病理特征和质量评估的数据.
主要成果:
- 在存在LT时,PTC-BRAF的几率显著降低 (OR0.53,p < 0.00001).
- PTC-BRAF与诸如中央部节点疾病和甲状腺外延伸等不良特征有关.
- 与没有LT的PTC相比,具有LT的PTC显示出更好的预后因素 (结节疾病的几率较低,瘤大小较大,甲状腺外延伸,晚期AJCC阶段)
- 无论是BRAF突变还是LT都没有显著影响PTC复发 (分别为OR 1.12和0.60).
结论:
- 存在LT与PTC-BRAF的流行率显著降低有关.
- 带有LT的PTC表现出更有利的预后特征,独立于BRAF状态.
- 需要进一步的研究来探索LT对PTC-BRAF的抑制作用及其对免疫治疗的影响.
相关概念视频
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
The Ras Gene
6.2K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
Ras is a...
6.2K
Cancer-Critical Genes I: Proto-oncogenes
8.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.8K
The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K

