阿斯塔山丁对小鼠因印米他辛诱导的胃的保护作用
Mohamed H Aly1,2, Aya K Said3,4, Aya M Farghaly5
1Pharmacology Department, Faculty of Pharmacy, The British University in Egypt, Cairo, 11837, Egypt. mohamed.aly@bue.edu.eg.
Naunyn-Schmiedeberg's archives of pharmacology
|June 28, 2024
概括
作为一种海洋抗氧化剂的阿斯丁,通过减少氧化应激和炎症,有效地保护小鼠免受非类固醇抗炎药物诱导的胃. 它的保护作用与奥梅普拉相当,突出了其作为胃健康营养药的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 营养学科学 营养学科学
背景情况:
- 胃潰瘍疾病是一個重要的健康問題,經常是由導致氧化壓力和炎症的非類固醇抗炎藥物 (NSAIDs) 引起的.
- 作为一种来自海洋来源的强效抗氧化剂,阿斯丁因其营养学潜力而闻名.
研究的目的:
- 在小鼠模型中研究阿斯塔克桑丁对因因多美素引起的胃的保护作用.
- 探索阿斯塔克桑抗性活性的潜在机制.
主要方法:
- 二十四只小鼠被分为对照组,印梅他辛,奥梅普拉治疗组和阿斯塔克桑治疗组.
- 胃组织分析了总体形态,分数,酸度,谷氨 (GSH),甲酸 (MDA),核因子-卡帕B (NF-κB) 和卡斯巴-3水平.
- 进行了组织病理学和免疫组织化学分析.
主要成果:
- 印梅他辛的使用显著增加了胃,降低了GSH,并提高了MDA,NF-κB和caspase-3水平.
- 阿斯塔桑预治疗显著增加了胃的pH值,使GSH水平正常化,并减少了MDA,NF-κB和caspase-3.
- 阿斯塔克桑丁的保护作用与梅zol相似.
结论:
- 阿斯塔桑丁在小鼠中表现出显著的抗原性质,可以对抗印梅他辛诱导的胃损伤.
- 它的保护作用归因于其抗氧化,抗炎和抗丧活性.
- 阿斯塔克桑作为NSAID诱导的胃的治疗剂显示出希望.
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