缺血预调对血管功能的远程和局部影响:累积效益的案例
Bert Bond1, Harrison Hurlstone1, David M Köditz1
1Public Health and Sport Sciences, University of Exeter, Devon, United Kingdom.
概括
肢体缺血和再输的短周期 (缺血预条件或IPC) 改善了血管功能. 观察到本地和远程效应,流媒扩张 (FMD) 的益处随着IPC重复会议的增加而增加.
科学领域:
- 生理学 生理学 生理学
- 血管生物学 血管生物学
- 运动科学 运动科学
背景情况:
- 缺血预先调节 (IPC) 涉及短暂的,重复的肢体缺血和再注血周期.
- IPC已经显示出保护血管损伤的潜力.
- 关于IPC对静止血管功能的影响的研究有限,特别是在单次或重复的疗程后,局部与远程效应.
研究的目的:
- 调查单个IPC会话的本地和远程宏血管和微血管效应.
- 为了检查两周内重复的IPC会话对血管的影响.
- 为了比较单次与重复的IPC对血管功能的影响.
主要方法:
- 健康的成年人在一臂接受了IPC (4x5分钟缺血).
- 测量了宏血管功能 (流媒体扩张,口腔疾病) 和微血管功能 (皮肤血管导电率,CVC).
- 测量是在单次IPC前,立即后,20分钟后和24小时后进行的,以及两周内六次IPC会议后的24小时.
主要成果:
- 在一次IPC会话后20分钟,受过训练和未受过训练的手臂中,口腔炎和CVC的增加.
- 这些血管功能改善在单次IPC后的24小时内没有持续.
- 在六次IPC疗程后的24小时内,两只手臂的流媒扩张 (FMD) 升高,但皮肤血管导电率 (CVC) 没有改变.
结论:
- IPC的局部和远程血管效应似乎是相当的.
- 与单次暴露相比,持续的IPC培训可能为宏血管功能 (FMD) 提供更大的好处.
- IPC是一种潜在的非药物干预,可以改善血管健康.
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