在急性胰腺炎中循环性亡标志物
Hanna Belfrage1, Krista Kuuliala2, Antti Kuuliala2
1Department of Surgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, 00290, Helsinki, Finland. hanna.belfrage@hus.fi.
Digestive diseases and sciences
|June 28, 2024
概括
干白素-6 (IL-6) 和sST2水平可以预测严重的急性胰腺炎 (AP). 升高的MLKL表明AP的器官衰竭,这表明亡途径是疾病进展和潜在治疗点的关键.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 死亡,一个被编程的炎症性细胞死亡,有助于急性胰腺炎 (AP) 的发病.
- 关键的亡执行者蛋白包括MLKL,RIPK1和RIPK3.
- 介素-33 (IL-33) 和其可溶性受体 (sST2) 参与炎症反应.
研究的目的:
- 为了比较不同AP严重程度和阶段的亡标志物和细胞因子的水平.
- 研究这些标志物在AP发展和进展中的预后价值.
主要方法:
- 分析了来自轻度AP (MAP),严重AP (SAP),有或没有器官衰竭 (OF),晚期SAP和健康对照 (HC) 患者的血样本.
- 与酶相关的免疫吸收试验 (ELISA) 用于量化IL-33,sST2,MLKL,RIPK1,RIPK3,IL-6,TNF和IL-1β.
主要成果:
- 早期的sST2和IL-6水平预测了SAP的发展,并且与HC相比,在MAP和SAP中升高.
- 与HC相比,在患有SAP或患有SAP的患者中,RIPK3水平更高.
- MLKL水平与OF相关,特别是在晚期AP中,并且在MAP中也升高.
结论:
- sST2,RIPK3和IL-6显示出作为AP的预后生物标志物的潜力.
- 升高的MLKL水平与AP的器官衰竭有关.
- 对于开发向治疗来说,进一步研究AP中亡是至关重要的.
相关概念视频
01:27Acute Pancreatitis I: Introduction
353
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
353
01:30Acute Pancreatitis II: Clinical Manifestations and Management
118
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
118
01:24Chronic Pancreatitis I: Introduction
86
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
86
01:16Necrosis
4.4K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.4K