戒烟药疗在怀孕期间使用
Annelies L Robijn1, Duong T Tran1, Jacqueline M Cohen2
1National Drug and Alcohol Research Centre, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
JAMA network open
|June 28, 2024
概括
这项研究发现怀孕期间使用瓦雷尼克林和布洛普里昂的比例较低,符合指导方针. 尼古丁替代疗法 (NRT) 的使用率更高,大多数发生在头三个月,突出了需要安全数据的需要.
科学领域:
- 生殖健康 生殖健康
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 关于在怀孕期间戒烟药物治疗的安全性存在证据缺陷,特别是关于先天性形.
- 专业机构建议谨慎使用尼古丁替代疗法 (NRT),并建议在怀孕期间不要服用瓦雷尼克林和布洛.
- 目前关于在孕妇中使用戒烟药物治疗的估计不足.
研究的目的:
- 为了量化在怀孕期间使用处方戒烟药物治疗的患病率.
- 具体评估在怀孕第一季度使用的比例.
- 分析四个高收入国家的使用模式.
主要方法:
- 使用了基于人口的回顾性队列研究设计.
- 数据来源于链接的出生,住院和药物发行记录.
- 该研究包括了2015年至2020年期间在澳大利亚,新西兰,挪威和瑞典所有导致分娩的怀孕.
主要成果:
- 瓦雷尼克林的总体患病率从0.02%到0.14%,NRT从<0.01%到1.86%,布洛从<0.01%到0.07%不等.
- 在吸烟的孕妇中,药物治疗使用率更高,瓦伦尼克林的最大患病率为1.25%,NRT为11.39%,布普罗为0.39%.
- 第一个三个月的使用率超过了瓦伦尼克林的90%,NRT的约60%,布普罗的80-90%.
结论:
- 瓦雷尼克林和布罗的低患病率和较高的NRT使用率与目前的临床准则一致,用于怀孕期间戒烟.
- 在怀孕的第一季度,这些药物的使用占主导地位,强调迫切需要关于先天性形风险的强有力的证据.
- 进一步的研究对于为孕妇提供安全有效的戒烟策略至关重要.
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