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身体质量指数在家庭几代人间的遗传性
Gabriel Chodick1, Maya Simchoni2,3, Britt Wang Jensen4
1Department of Epidemiology and Preventive Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
JAMA network open
|June 28, 2024
概括
父母的体重指数 (BMI) 显著影响后代的BMI,遗传因素对青少年的BMI遗传性有很大影响. 这凸显了家庭病史在了解体重状况方面的重要性.
科学领域:
- 遗传学和人类生物学
- 公共卫生 公共卫生
- 儿科内分泌学 儿科内分泌学
背景情况:
- 体重指数 (BMI) 的家族聚合表明,遗传性在体重状况中起着重要作用.
- 了解BMI的遗传贡献对于制定有效的公共卫生策略来应对肥胖至关重要.
研究的目的:
- 通过检查父母和后代BMI之间的关联来量化身体质量指数 (BMI) 的遗传性.
- 评估父母的BMI状态对后代肥胖的可能性的影响.
主要方法:
- 这是一项大型队列研究,利用1986-2018年以色列强制性兵役医疗查数据.
- 使用斯皮尔曼相关系数和逻辑回归模型来分析与父母的BMI相关的BMI关联和肥胖率比率.
- 包括超过447,000名后代及其父母,他们的BMI测量是在17岁时进行的.
主要成果:
- 在17岁的中期父母BMI百分位数和后代BMI之间观察到中度相关性 (ρ=0.386).
- 父母肥胖与子女肥胖的几率增加密切相关 (OR=6.44).
- 17岁BMI的狭义遗传率估计为39%.
结论:
- 遗传因素在青少年时期的BMI变化中起着重要作用.
- 父母的BMI是后代BMI和肥胖风险的重要预测因素.
- 这些发现强调了家庭对青少年体重管理的影响的重要性.
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