阻断性睡眠呼吸暂停在患有初级阿尔多斯特罗尼斯症的患者中的患病率
Jia-Yuh Sheu1, Li-Yang Chang2, Jui-Yi Chen3,4
1Department of Urology, National Taiwan University Hospital, Taipei 100225, Taiwan.
The Journal of clinical endocrinology and metabolism
|June 28, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 在原发性阿尔多斯顿症 (PA) 患者中很常见,影响近60%. 脏过与这些高血压个体中较高的OSA患病率有关.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肺部病理学 肺部病理学
背景情况:
- 调查阻塞性睡眠呼吸暂停 (OSA) 和原发性阿尔多斯特隆症 (PA) 的同时发生对于理解它们的相互关系至关重要.
- 这两种情况都在高血压患者中普遍存在,这表明潜在的共享病理生理机制.
研究的目的:
- 为了评估在被诊断为PA的患者中OSA的患病率.
- 评估患有OSA的患者中PA的患病率.
- 专注于两种人群中的高血压患者.
主要方法:
- 在主要数据库 (PubMed,Embase,CINAHL,Scopus,Web of Science) 进行了详尽的文献搜索,截至2023年9月.
- 选择了研究,重点关注OSA在PA患者和PA在OSA患者的患病率,特别是在高血压队列中.
- 数据提取遵循标准指南,重点关注流行率和相关临床参数.
主要成果:
- 在高血压PA患者中发现OSA的患病率为59.8%,其中45.4%的OSA为中度至重度.
- 在OSA患病率和球过率 (GFR),特别是过率 (GFR≥100mL/min每1.73m2) 之间观察到显著的积极关联.
- 在高血压的OSA患者中,11.2%被诊断为PA.
结论:
- 在PA患者中存在大量的OSA患病率,突出显示高血压患者的复杂相互作用.
- 该研究发现,在这个人群中,OSA患病率和脏过之间存在显著的关联.
- 这些发现强调了在PA患者中查OSA的重要性,反之亦然,特别是在高血压患者中.
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