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Assessment of Child Anthropometry in a Large Epidemiologic Study
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西班牙裔儿童的炎症标志物和体重指数
Henry Lang1, Elaine N Loudermilk2, W Andrew Clark3
1College of Medicine, Oklahoma State University, Stillwater, OK, United States of America.
PloS one
|June 28, 2024
概括
在西班牙裔儿童中,较低的阿迪波涅克丁和较高的胰岛素水平与超重/肥胖有关. 在这个年轻人群中,阿迪波涅丁可能是代谢健康的关键标志物.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢健康研究 代谢健康研究
- 肥胖研究 肥胖研究
背景情况:
- 成人研究表明,身体质量指数 (BMI) 和脂肪素之间的关系是逆的.
- 成年人BMI升高与胰岛素,C-反应蛋白 (CRP),干白素6 (IL-6),电阻素和瘤缩因子-α (TNF-α) 有关.
- 关于这些生物标志物与西班牙裔儿科人口的BMI相关的数据有限.
研究的目的:
- 研究西班牙裔年轻人的炎症标志物和超重/肥胖之间的关联.
- 为了控制田纳西州东北部的社会人口因素.
- 检查与超重/肥胖相关的阿迪波内克丁,胰岛素,抵抗素,CRP,TNF-α和IL-6.
主要方法:
- 田纳西州东北部的107名西班牙裔儿童 (2-10岁) 提供了身高,体重,人口统计数据和血液样本.
- 使用多变量逻辑回归分析.
- 评估了生物标志物 (阿迪波涅克丁,胰岛素,抵抗素,CRP,TNF-α,IL-6) 和超重/肥胖之间的关联.
主要成果:
- 超重/肥胖的西班牙裔儿童的阿迪波内克水平明显较低 (p=0.0144).
- 在超重/肥胖的西班牙裔儿童中观察到更高的胰岛素水平 (p=0.0048).
- 电阻素,IL-6,TNF-α和CRP没有与超重/肥胖有显著的关联.
结论:
- 在西班牙裔青年中,阿迪波涅克丁水平与其他儿科组的发现相匹配.
- 阿迪波内克丁可以作为一种有价值的生物标志物,用于评估西班牙裔儿童的代谢健康状况.
- 在这个人群中,胰岛素与超重/肥胖有显著的关联.
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