双抗体血清消极神经炎视网膜变化 光学谱系障碍
Frederike C Oertel1, Hanna G Zimmermann1, Seyedamirhosein Motamedi1
1From the Experimental and Clinical Research Center (F.C.O., H.G.Z., S.M., C.B., L.M.M., A.U.B., F.P.), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin; Neuroscience Clinical Research Center (F.C.O., H.G.Z., S.M., C.B., L.M.M., A.U.B., F.P.); Department of Neurology (F.C.O., F.P.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin; Einstein Center Digital Future (H.G.Z.), Berlin, Germany; Kashani MS Center (F.A.), Isfahan University of Medical Sciences; School of Advanced Technologies in Medicine and Medical Image and Signal Processing Research Center (R.K.); Department of Ophthalmology (A.D., M. Pourazizi), Isfahan Eye Research Center, Isfahan University of Medical Sciences, Iran; Department of Neurology (L.P., A.D.C.), KS Hegde Medical Academy, Nitte University, Mangalore, India; Department of Neurology (O.A., P.A., M. Ringelstein), Medical Faculty, Heinrich Heine University Düsseldorf; Department of Neurlogy (P.A.), Kliniken Maria Hilf Mönchengladbach; Centre for Neurology and Neuropsychiatry (M. Ringelstein), Landschaftsverband Rheinland-Klinikum Düsseldorf, Medical Faculty, Heinrich Heine University Düsseldorf, Germany; Hospital Clinic of Barcelona-Institut d'Investigacions (E.H.M.-L., B.F.S.D., P.V.), Biomèdiques August Pi Sunyer, (IDIBAPS), Barcelona, Spain; Departments of Neurology (N.A.), Slagelse Hospitals, Denmark, Institute of Regional Health Research; Institute of Molecular Medicine (N.A.), University of Southern Denmark, Odense, Denmark; Service de Neurologie (R.M., A.C.-C.), Sclérose en Plaques, Pathologies de la Myéline et Neuro-inflammation, Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France; Centre d'Esclerosi Múltiple de Catalunya (Cemcat) (A.C.-C.), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Spain; Experimental Neurophysiology Unit (L.L., M. Pisa, M. Radaelli), Institute of Experimental Neurology (INSPE) Scientific Institute San Raffaele and University Vita-Salute San Raffaele, Milan, Italy; Department of Neurology (J.P., A.R.-F., M.I.S.L.); Department of Ophthalmology (S.S.), Oxford University Hospitals, National Health Service Trust, United Kingdom; Neurology Service (J.D.S., T.S.), University Hospital of Strasbourg, France; Department of Medicine (M.R.Y.), Divisions of Molecular Medicine and Infectious Diseases, Harbor-University of California at Los Angeles (UCLA) Medical Center, and Lundquist Institute for Biomedical Innovation, Torrance; Department of Medicine (M.R.Y.), David Geffen School of Medicine at UCLA, Los Angeles; Departments of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center; Division of Metabolism (T.J.S.), Endocrine and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; and Department of Pediatrics (L.J.C.), University of Utah.
双抗体血清消极神经炎光学谱系障碍 (DN-NMOSD) 导致显著的视网膜损伤,甚至在视神经炎之前. 由于快速的神经轴损失,早期诊断和治疗至关重要.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 神经脊髓炎光学谱系障碍 (NMOSD) 是一种影响中枢神经系统的自身免疫性疾病.
- 双抗体血清阴性NMOSD (DN-NMOSD) 缺乏特定的抗体,使得诊断具有挑战性.
- 视网膜干扰是NMOSD的一个关键特征,但其在DN-NMOSD中的程度尚未完全理解.
研究的目的:
- 系统地描述DN-NMOSD的临床表现,重点关注视网膜变化.
- 为了将DN-NMOSD中的视网膜神经退行与水-4抗体血清阳性NMOSD (AQP4-NMOSD) 和健康对照 (HC) 进行比较.
主要方法:
- 截面研究包括25名DN-NMOSD患者,25名AQP4-NMOSD患者和25名HC患者,根据年龄和性别进行匹配.
- 光学连贯断层扫描 (OCT) 用于测量周状视网膜神经纤维层厚度 (pRNFL) 和状细胞内状层厚度 (GCIPL).
- 进行了神经学检查和抗体测试.
主要成果:
- DN-NMOSD患者的中位数为6次发作,骨髓炎和视神经炎 (ON) 是最常见的.
- 在ON后的DN-NMOSD眼睛中观察到视网膜神经退行 (较薄的pRNFL和GCIPL),与HC相比.
- 显著的神经轴损失甚至在单次ON事件后也显而易见,并且在DN-NMOSD眼睛中也没有ON史.
- 在DN-NMOSD和AQP4-NMOSD组之间没有发现视网膜层厚度的显著差异.
结论:
- DN-NMOSD的特征是严重的视网膜损伤,包括攻击独立的神经退行.
- 大多数视网膜损伤发生在最初的ON发作期间,强调了早期诊断和治疗的必要性.
- 同质的临床和成像发现表明DN-NMOSD中常见的视网膜病理.
更多相关视频
09:29Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
10:14Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
相关概念视频
Photoreceptors and Visual Pathways
Diabetic Retinopathy
