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Updated: Jun 22, 2025

A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage
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A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage

Published on: May 10, 2022

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优化T-PLL的药物组合:恢复DNA损伤和P53介导的亡反应

Jana von Jan1,2,3, Sanna Timonen4,5,6, Till Braun1,2,3

  • 1Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.

Blood
|June 28, 2024
PubMed
概括

这项研究确定了有效的药物组合,包括cladribine和MDM2抑制剂,用于治疗T-prolymphocytic白血病 (T-PLL). 这些疗法在临床前模型中通过恢复P53功能和增强亡,显示出有希望的前临床模型,为T-PLL治疗提供了新的希望.

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