脂蛋白,氧化脂和冠外血管疾病之间的关联
Tiffany R Bellomo1, Yuxi Liu2, Thomas C Gilliland3
1Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, MA, USA.
Journal of lipid research
|June 28, 2024
概括
升高的脂蛋白 (Lp) 是冠外血管疾病和主要不良肢体事件 (MALE) 的重要危险因素. 将氧化脂 (OxPLs) 添加到Lp(a) 测量结果中,并不能改善这些疾病的风险预测.
科学领域:
- 心血管医学 心血管医学
- 动脉样硬化研究 动脉样硬化研究
- 血管生物学 血管生物学
背景情况:
- 脂蛋白 (Lp) 和氧化脂 (OxPLs) 涉及到冠状动脉疾病.
- 它们在冠外血管疾病 (ECVD) 和相关风险中的作用仍然不太清楚.
研究的目的:
- 调查Lp(a),OxPL Apolipoprotein B (OxPL-apoB) 和OxPL Apolipoprotein ((a) (OxPL-apo(a)) 与血管学ECVD的相关性.
- 评估它们对主要不良四肢事件 (MALEs) 的预测价值.
主要方法:
- 对446名接受冠状动脉和/或外周血管造影的参与者的分析.
- 在血管造影之前测量Lp (a),OxPL-apoB和OxPL-apo (a) 的水平.
- 随访时间平均为3.7年,以评估事件MALE.
主要成果:
- 升高的Lp (a) 与ECVD存在的关联比OxPLs更强.
- 升高的Lp (a) 独立预测的MALE (OR 2.14),在添加OxPLs时得到的改善很小.
- 单独的Lp (a) 有效地捕捉了与Lp (a) 和OxPLs相关的外周动脉动脉样硬化风险.
结论:
- 升高的Lp (a) 是ECVD进展和MALE的一个关键风险因素.
- 对于ECVD风险,OxPL-apoB和OxPL-apo (a) 没有提供超出Lp (a) 的额外预测信息.
- 仅通过Lp测量就足以评估外围动脉动脉硬化风险.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
154
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
154
Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Inflammation
53.3K
Overview
53.3K
Cholesterol: Significance and Regulation
535
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
535
Overview of Lipid Metabolism
1.4K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.4K
Lipids: Dietary Sources and Requirements
720
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
720


