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Updated: Jun 22, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

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Published on: February 6, 2019

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在一个1,4-环基PROTAC链接器中,立体化学反向微调调整了结合性和结合亲和度的形状

Martina Pierri1, Xingui Liu1, Alena Kroupova1

  • 1Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, United Kingdom.

Bioorganic & medicinal chemistry letters
|June 28, 2024
PubMed
概括

蛋白质溶解向嵌合体 (PROTACs) 中的立体化学显著影响E3酶的结合和降解. 一种跨环基PROTAC连接剂,尽管结合较弱,但通过改变形状和三元复合体形成来增强降解.

关键词:
结合性亲缘关系是一种结合性亲缘关系.形状的形成 形状的形成链接器 链接器这就是PROTAC.立体中心是立体中心.这是VHLVHL.

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