生殖性毒素的职业暴露极限 - - 一个比较分析
Linda Schenk1, Meng-Rung Ho1, Piia Taxell2
1Integrative Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Reproductive toxicology (Elmsford, N.Y.)
|June 28, 2024
概括
职业暴露限值 (OEL) 和衍生无效水平 (wDNEL) 不能充分保护对生殖有毒物质的保护. 许多物质缺乏适当的暴露限值,现有的暴露限值差异很大,有些物质的安全边际不足.
科学领域:
- 职业健康和安全问题 职业健康和安全问题
- 毒理学 毒理学 毒理学
- 化学品风险评估 化学品风险评估
背景情况:
- 职业暴露限值 (OEL) 和工人吸入暴露的衍生无效水平 (wDNEL) 对于保护工人免受生殖和发育毒性至关重要.
- 这些极限在覆盖已知的生殖毒性物质方面的有效性需要彻底调查.
研究的目的:
- 评估OELs和wDNELs对生殖和发育毒性的保护.
- 为了比较各种OEL和WDNEL生殖毒素清单的覆盖范围,数值和科学基础.
主要方法:
- 对14个OEL和wDNEL清单的比较,与被统一分类为生殖毒素1A或1B的物质进行比较.
- 分析物质覆盖范围,数值,科学基础和生殖毒性安全差距.
主要成果:
- 只有53%的生殖毒素在审查的清单中至少有一个暴露限值.
- 登记者的wDNEL占据了最大的份额 (40%),但数值差异很大.
- 发现15%的安全边际对于生殖毒性不足.
结论:
- 目前的OEL和wDNEL在REACH和工作环境立法中没有足够覆盖已知的生殖毒素.
- 与其他清单相比,欧盟的OEL涵盖的物质较少,国家OEL/wDNEL通常更保守.
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