由双a (BPA) 和其替代品诱导的非编码RNA在人类疾病中的新兴调控作用
Bo He1, Hai-Ming Xu2, Shu-Wei Li3
1Department of Emergency Internal Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, China.
Environmental pollution (Barking, Essex : 1987)
|June 28, 2024
概括
双 (BPs) 破坏内分泌功能,并通过表观遗传学影响健康. 本综述强调了非编码RNAs (ncRNAs) 作为BP相关疾病的关键参与者,将其确定为潜在的生物标志物和治疗点.
科学领域:
- 环境健康 环境健康
- 分子生物学分子生物学
- 毒理学 毒理学 毒理学
背景情况:
- 双 (BPs) 是合成的内分泌干扰化学物质,广泛用于塑料.
- 暴露于BP,特别是BPA,与由核激素受体介导的人类疾病有关.
- 乙A可以通过DNA甲基化和基因素乙化在表观遗传上影响人类健康.
研究的目的:
- 审查非编码RNAs (ncRNAs) 在BP诱导的人类疾病中的调控作用.
- 阐明涉及ncRNAs的BP相关疾病背后的分子机制.
- 为了确定潜在的ncRNA生物标志物和BP暴露的治疗点.
主要方法:
- 关于BP和ncRNA的研究的文献综述和生物信息分析.
- 对BP诱导疾病中ncRNA调节的当前知识的综合.
- 在BP毒性中涉及的特定ncRNAs (miRNAs, lncRNAs, circRNAs, snoRNAs) 的鉴定.
主要成果:
- ncRNAs,包括miRNAs,lncRNAs,circRNAs和snoRNAs,在与BP相关的疾病中起着重要作用.
- 在ncRNAs的变化与正常的细胞功能和BP诱导的病理有关.
- ncRNAs涉及各种与BP相关的疾病,影响生殖,神经,消化和内分泌系统.
结论:
- ncRNAs对于调解双暴露对健康的影响至关重要.
- 特定的ncRNAs显示为诊断和监测BP相关疾病的生物标志物具有前途.
- 向ncRNAs为减轻双毒性和相关人类疾病提供了潜在的治疗策略.
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