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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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解码灰色物质参与多发性硬化症通过成像.

Robert Zivadinov¹, Ferdinand Schweser¹, Dejan Jakimovski²

¹Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.

Neuroimaging clinics of North America

|June 28, 2024

概括

此摘要是机器生成的。

多发性硬化症涉及到灰质 (GM) 损伤,而不仅仅是白质. 这种灰质病理显著推动了MS患者的疾病进展.

关键词:

3T 3T 3T 3T 3T 3T 3T 3T 3T 3T 3T 3T 7T 7T 7T 7T 7T 7T 7T 7T 7T 7T 7T 7T 7T 7T 7T 缩性缩症缩性缩症皮层病变在皮层病变.灰色物质是一种灰色物质.铁的度是铁的度.勒普托门炎的炎症病理学病理学病理学

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科学领域:

神经成像是一种神经成像.
神经学神经学
病理学病理学病理学

背景情况:

多发性硬化症 (MS) 传统上被视为一种白质疾病.
新出现的证据突出显示,灰色物质 (GM) 在多发性硬化症病理中具有显著的参与.
灰质损伤有助于MS (pwMS) 患者的疾病进展.

研究的目的:

总结对MS灰质病理学的理解.
强调转基因损伤作为MS进展的驱动因素的作用.
倡导将转基因成像生物标志物的临床整合.

主要方法:

使用先进的磁共振 (MR) 成像技术 (7T和3T) 的研究审查.
对优化的MRI成像协议进行分析,以检测转基因变化.
对MS患者的转基因病理学发现的综合分析.

主要成果:

多发性硬化中的灰质病理包括病变,脑膜炎,缩和微观结构变化.
先进的MRI成像证实了转基因损伤是疾病进展的主要驱动因素.
转基因成像生物标志物对于评估疾病严重程度和治疗反应至关重要.

结论:

灰质病理是多发性硬化症的关键组成部分.
先进的神经成像技术揭示了MS中转基因损伤的程度.
将转基因成像生物标志物纳入临床实践对于管理多发性硬化症至关重要.