对呼吸道感染进行药物改用
Juveriya Israr1, Shabroz Alam2, Ajay Kumar3
1Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Barabanki, Uttar Pradesh, India; Department of Biotechnology, Era University, Lucknow, Uttar Pradesh, India.
Progress in molecular biology and translational science
|June 28, 2024
概括
药物重新定位提供了一个快速,经济有效的策略,以寻找新的治疗方法,用于呼吸道感染,如冠状病毒病 2019. 这种方法重复使用现有药物,加速治疗方法的开发,以应对全球卫生挑战.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 呼吸道感染,包括2019年新冠病毒病,对全球健康构成重大风险,特别是对弱势群体.
- 传统药物开发受到长时间,高成本和日益增长的抗菌素耐药性的阻碍.
研究的目的:
- 审查用于呼吸道感染的药物的重新用途方面的进展和挑战.
- 突出药物再利用作为有效的治疗策略的潜力.
主要方法:
- 总结目前药物重定向用于呼吸道感染的进展情况.
- 探索计算方法,高通量查和临床前研究以确定候选药物.
- 检查重新用途药物的监管方面和临床试验设计.
主要成果:
- 确定了重用药物的显著例子及其作用机制.
- 强调了计算和选方法在识别可行的药物候选者的作用.
- 强调了监管途径和临床验证对重定向疗法的重要性.
结论:
- 药物重新定位是一种有价值和有效的方法,可以扩大呼吸道感染的治疗选择.
- 这一战略可以改善患者的治疗结果,并减少全球疾病负担.
- 进一步的研究和临床验证对于成功实施至关重要.
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