卵巢微环境:预防与化疗相关的卵巢损伤的挑战和机会
Yican Guo1,2,3, Liru Xue1,2,3, Weicheng Tang1,2,3
1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Human reproduction update
|June 28, 2024
概括
化疗可以通过改变卵巢微环境来损害卵巢功能. 针对这种微环境提供了一种有希望的策略,以保护接受癌症治疗的妇女的生育能力和卵巢储备.
科学领域:
- 生殖生物学和瘤学.
- 卵巢损伤的细胞和分子机制.
背景情况:
- 化疗相关的卵巢损伤 (CAOD) 是绝经前妇女的一个重大问题,导致荷尔蒙失衡,不孕症和过早更年期.
- 虽然已知直接的卵泡损伤,但新出现的证据强调了卵巢微环境在CAOD中的关键作用.
- 卵巢微环境支持卵泡的发育和功能,化学疗法期间的破坏会影响卵巢的整体健康.
研究的目的:
- 在化疗期间审查卵巢微环境的变化.
- 强调针对CAOD的新疗法准卵巢微环境的重要性.
- 突出针对微环境的策略,以保护卵巢功能的潜力.
主要方法:
- 在PubMed的综合文献搜索到2024年4月.
- 包括与卵巢微环境组件,卵巢功能和各种化疗剂相关的术语.
- 对CAOD和卵巢微环境的现有研究进行系统审查和综合.
主要成果:
- 化疗显著改变卵巢微环境,导致纤维化,血管生成障碍,免疫失调,氧化应激,干细胞枯竭和衰老.
- 这些微环境变化导致卵巢毛囊的数量和质量下降.
- 针对微环境的治疗策略,包括干细胞治疗,自由基清除剂,老化剂,免疫调节剂和益血管性因素,已经显示出潜在的潜力.
结论:
- 卵巢微环境,类似于"土壤",对于卵巢"种子" (卵泡) 至关重要,并在CAOD中发挥着至关重要的作用.
- 准卵巢微环境为预防和治疗CAOD提供了一个有希望的治疗途径.
- 需要对CAOD中的卵巢微环境的调节网络进行进一步的研究,以开发用于保持卵巢功能的创新策略.
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