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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

510
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
510
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

888
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
888
Cancer Vaccines01:30

Cancer Vaccines

351
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
351
Immunological Memory01:23

Immunological Memory

585
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
585
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

699
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
699
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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相关实验视频

Updated: Jun 22, 2025

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

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注意你的时间:它对免疫疗法很重要.

Nicolas Cermakian1, Nathalie Labrecque2

  • 1Douglas Research Centre, Montréal, Québec, H4H 1R3, Canada; Department of Psychiatry, McGill University, Montréal, Québec, H3A 1Y2, Canada.

Trends in cancer
|June 28, 2024
PubMed
概括

循环节律可能会影响癌症免疫治疗的有效性. 研究表明,优化治疗时间可以增强对瘤的免疫反应,类似于化疗优化.

关键词:
在PD-1中使用PD-1.癌症免疫疗法免疫疗法昼夜时钟是生物周期的时间表.昼夜节律是指昼夜节律的节奏.免疫检查点抑制剂 免疫检查点抑制剂

更多相关视频

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

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相关实验视频

Last Updated: Jun 22, 2025

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
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Published on: June 7, 2024

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

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科学领域:

  • 免疫学 免疫学 免疫学
  • 时间生物学 时间生物学
  • 癌症研究 癌症研究

背景情况:

  • 癌症免疫疗法通过利用免疫细胞来彻底改变瘤治疗.
  • 优化治疗时间已在化疗中确立,但对免疫治疗的理解较少.
  • 最近的研究调查了昼夜节律在癌症免疫治疗中的作用.

研究的目的:

  • 为了确定白天的时间是否影响癌症免疫治疗的疗效.
  • 在癌症免疫治疗的背景下探索化疗原则的潜力.

主要方法:

  • 在Cell上发表的一项研究调查了治疗时间对免疫治疗结果的影响.
  • 方法可能涉及分析临床前模型或患者数据,将治疗计划与反应率相关联.

主要成果:

  • 研究结果表明,免疫治疗的时间可能会影响治疗的有效性.
  • 一天中的特定时间可能更有利于建立抗瘤免疫反应.

结论:

  • 白天的时间是优化癌症免疫治疗的潜在关键因素.
  • 对时间疗法的进一步研究可能会导致癌症患者改善治疗策略.