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在早产的个体中,抗氧化剂和神经发育基因多态性会影响缺氧相关的氧化应激

Katja Goričar¹, Tadej Debevec^2,3, Vita Dolžan¹

¹Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Scientific reports

|June 28, 2024

概括

过早分娩 (PTB) 可能会影响年轻人如何在运动期间处理氧化应激. 特定的基因变异会影响这些反应,影响婴儿期后很长一段时间的健康.

科学领域:

生理学生理学生理学
遗传学是一个遗传学.
环境健康环境健康

背景情况:

过早分娩 (PTB) 与氧化应激损伤有关.
研究PTB对氧化应激标志物的长期影响至关重要.
基因多态可能调节氧化应激反应.

研究的目的:

为了检查抗氧化和神经发育基因多态性和氧化应激参数之间的关系,在早产 (PTB) 和出生后对照的年轻成年男性中.
为了评估这些协会在休息和运动期间在正常和缺氧条件下.

主要方法:

研究包括健康的年轻男性:22名PTB和15名到期出生.
参与者在normoxic (FiO2=0.21) 和 hypoxic (FiO2=0.13) 条件下进行了分级运动测试.
分析了氧化应激参数和基因多态 (CAT,GPX1,HIF1A,NOTCH4,BDNF) 的情况.

主要成果:

CAT rs1001179与PTB个体中酸盐的降低有关.
GPX1 rs1050450与适时出生的个体抗氧化能力降低有关.
NOTCH4 rs367398显示,在低氧状态下与增加的氧化应激标志物有关,而在正常状态下与马隆迪化物有关.
BDNF rs6265与PTB个体中酸盐/酸盐的降低有关.

结论:

基因多态性和早产史可以影响氧化应激对运动的反应.
这些影响持续到年轻的成年期,影响在normoxic和hypoxic环境中的反应.
研究结果强调了早产对氧化应激调节的长期生理影响.

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