Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

72
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
72
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

105
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
105

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The role of the molecular tumor board: learnings from the ROME trial.

NPJ precision oncology·2026
Same author

PSOGI consensus on minimally invasive surgery for peritoneal surface malignancy.

The British journal of surgery·2026
Same author

A tailored histology-driven molecular profiling algorithm proposal for salivary gland cancers.

ESMO open·2026
Same author

HER2-low breast cancer is immune-cold: insights into tumor-infiltrating immune cells and implications for immunotherapy.

NPJ breast cancer·2025
Same author

Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).

ESMO open·2025
Same author

Impact of molecular tests and precision oncology on patients with advanced thyroid carcinomas in a referral center: the OrienTHYring real-world study.

ESMO open·2025

相关实验视频

Updated: Jun 22, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.1K

硫酸盐成像识别结直肠癌中瘤细胞 腹转移

G M Sarcinelli1, L Varinelli2, S Ghislanzoni1

  • 1Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale Dei Tumori, Via G. Amadeo 42, 20133, Milan, Italy.

Cancer & metabolism
|June 29, 2024
PubMed
概括

矩阵辅助激光溶解/电离 - 飞行时间 (MALDI-TOF) 影像检测在结直肠癌 (CRC) 周周转移 (PM) 中发现了独特的脂质谱. 葡萄糖脂硫酸盐 (STs) 标记瘤细胞,而特定的酸丁醇 (PI) 被改变,为PM进展提供了潜在的治疗点.

关键词:
脂质 脂质 是一种马尔迪成像 - 图像成像器官类动物 器官类动物腹腔周周癌症的发生.硫酸盐化物 硫酸盐化物

更多相关视频

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

10.9K
Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells
08:47

Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells

Published on: August 21, 2012

17.3K

相关实验视频

Last Updated: Jun 22, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.1K
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

10.9K
Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells
08:47

Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells

Published on: August 21, 2012

17.3K

科学领域:

  • 在瘤学瘤学.
  • 生物化学 生物化学
  • 质谱测量质量谱测量

背景情况:

  • 结肠直肠癌 (CRC) 中的腹转移 (PM) 是常见的,尽管进行了积极的治疗,但预后不佳.
  • 脂质在瘤生长和攻击性中起着至关重要的作用.
  • 矩阵辅助激光消耗/电离 - 飞行时间 (MALDI-TOF) 质谱 (MS) 是识别生物标记物的强大工具.

研究的目的:

  • 使用MALDI-TOF MS和MALDI-TOF成像MS (MALDI-IMS) 调查患者衍生瘤器官 (PDO) 和临床PM样本的脂质资料.
  • 为了确定PM组织内脂质的组织分布.
  • 为了确定PM进展的潜在的基于脂质的治疗点.

主要方法:

  • 使用 MALDI-TOF MS 和 MALDI-IMS 在 PDO 和临床 PM 样本上.
  • 分析了脂质样本及其在瘤和肌区内的空间分布.
  • 量化特定的脂类物种,包括糖脂硫酸盐 (ST) 和酸丁醇 (PI).

主要成果:

  • 在PM组织内的瘤细胞中鉴定出一种独特的脂质特征,主要是硫酸盐 (ST),在树突区域缺失.
  • 含有阿拉基酸 (AA) 的酸氨基 (PI) 在树皮成分中表达高.
  • 与树皮细胞相比,瘤细胞显示PI物种的丰度更高,具有更短,更和的乙烯链 (C34和C36).

结论:

  • 独特的脂质特征,特别是改变的酸丁醇 (PI) 和硫酸盐 (ST) 物种,表明细胞颠覆促进瘤生长,攻击性和转移.
  • 涉及葡萄糖脂 (GSL) /STs的PM代谢编程呈现了潜在的新疗法点,以抑制PM进展.