视网膜周动脉与周静脉 Amyloidosis,海马缩和认知障碍:探索性试验
Oana M Dumitrascu1, Jonah Doustar2, Dieu-Trang Fuchs2
1Departments of Neurology, Mayo Clinic, AZ, 13400 E. Shea Blvd, Scottsdale, AZ, 85259, USA. dumitrascu.oana@mayo.edu.
Acta neuropathologica communications
|June 29, 2024
概括
视网膜粉样质斑 (AP) 在动脉中比静脉更常见,特别是在认知障碍患者中. 升高的静脉AP与认知衰退和阿尔茨海默病 (AD) 进展标志物相关.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 生物医学成像技术 生物医学成像技术
背景情况:
- 氨基粉症和血管系统越来越多地与认知障碍和阿尔茨海默氏症 (AD) 病原发生有关.
- 视网膜周血管粉样斑块 (AP) 的分布为大脑病理学提供了潜在的窗口.
研究的目的:
- 在正常和受损认知的个体中量化评估视网膜周血管AP分布.
- 为了与神经成像和神经认知测量相关联视网膜周血管性粉症.
主要方法:
- 对28名受试者的扫描激光眼镜光图像进行了回顾性分析.
- 新型图像处理以量化周动脉和周静脉黄素阳性AP负担.
- 与神经成像 (海马体积,白质超强度) 和认知得分 (CDR,MoCA) 的相关性分析.
主要成果:
- 在所有血管分支中,周动脉AP计数明显高于周静脉AP计数 (P < 0.0001).
- 认知障碍个体表现出增加的周动脉AP和升高的二级分支周静脉AP (P < 0.01).
- 周静脉AP计数,特别是在二级/三级静脉中,与认知衰退指标有很强的相关性.
结论:
- 观察到较大的周动脉 Amyloidosis,而不是周静脉 Amyloidosis,在认知障碍中,二次周静脉区域的沉积量增加.
- 视网膜周血管粉样蛋白成像显示了预测认知衰退和AD进展的潜力.
- 需要进一步的纵向研究来证实这些发现,并了解时空动态.
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