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小孩的皮质醇水平与母亲的产前抑郁症有关
Zaneta M Thayer1, Katherine L Nemeth2, Jade A Beauregard2
1Department of Anthropology, Dartmouth College, Hanover, New Hampshire, USA.
概括
母亲产前抑郁症与一年后幼儿的皮质醇水平较高有关. 这表明生命早期的压力会影响长期的压力生理学,可以通过头发皮质醇测量.
科学领域:
- 内分泌学 在内分泌学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 皮质醇是一种关键的代谢激素,调节许多生理系统.
- 早期的生活环境,特别是产前条件,显著影响皮质醇代谢.
- 与唾液或血清测量相比,毛皮质醇提供了独特的视角来了解下丘脑-垂体-上腺 (HPA) 轴功能.
研究的目的:
- 调查怀孕期间和分娩后母亲抑郁症与幼儿的母亲和后代头发皮质醇水平之间的联系.
- 探索母亲和他们的孩子头发皮质醇变化的预测因素.
主要方法:
- 对46名母亲和40名幼儿的长度评估 (平均年龄为15.6个月).
- 在怀孕期间和分娩后1个月评估的母亲抑郁症.
- 产妇和后代的皮质醇水平测量在出生后大约15个月.
主要成果:
- 孕产妇的抑郁症状在产前期最为明显.
- 产前母亲抑郁症,而不是产后抑郁症,与后代的皮质醇水平相关 (B=0.095,p=0.01).
- 在任何评估点上都没有发现母亲的皮质醇和抑郁症之间存在显著的关联.
结论:
- 一岁以上的后代的皮质醇水平与母亲的产前抑郁症有关.
- 在子宫内的条件,由母亲的产前抑郁症表明,可能会影响长期后代的压力生理学.
- 头发皮质醇为评估幼儿HPA轴动态提供了一个有价值的,最少侵入性的工具.
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