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睡眠微架构与阻塞性睡眠呼吸暂停的认知之间的关联

Andrew E Beaudin^1,2, Magdy Younes^3,4, Bethany Gerardy⁴

¹Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

|June 29, 2024

概括

阻塞性睡眠呼吸暂停 (OSA) 与认知能力下降有关. 特定的EEG睡眠测量,比如螺旋活动,可能有助于识别有风险的患者,并了解这种认知障碍背后的机制.

科学领域:

神经学神经学
睡眠医学睡眠医学
认知神经科学认知神经科学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是一种普遍的疾病,与认知障碍的风险增加有关.
早期识别患有OSA的个体有认知并发症的风险对于及时干预至关重要.
睡眠微架构的脑电图 (EEG) 测量提供了在OSA中认知功能障碍的潜在生物标志物.

研究的目的:

调查特定EEG睡眠微架构参数与疑似OSA的个体的认知功能之间的关联.
为了确定睡眠微架构指数是否调解OSA严重程度和认知表现之间的关系.

主要方法:

一组1142名被怀疑患有OSA的参与者接受了多睡眠和认知测试 (MoCA,RAVLT,DSC).
分析了包括睡眠线密度,功率,频率,百分比快线,赔率比率乘积 (ORP),正常化EEG功率 (EEGNP) 和delta:alpha比率在内的EEG测量.
使用多变量线性回归和中介分析来评估关联和中介效应,并根据相关共变量进行调整.

主要成果:

在中度至重度的OSA患者中观察到睡眠线索特征 (密度,功率,频率,%-fast) 的降低,并且与认知评分 (MoCA,RAVLT,DSC) 有积极的相关性,除了RAVLT的线索功率.
在NREM睡眠 (ORPNREM) 期间的几率比产物在严重的OSA中升高,但与认知评分没有显著关联.
调解分析表明,线密度和EEGNP部分调解了OSA对MoCA得分的影响,而ORPNREM,线功率和%快速线则调解了对DSC得分的影响.

结论:

睡眠旋转活动的改变,ORP和EEG功率的正常化被认为是OSA患者认知缺陷的重要贡献者.
这些来自EEG的睡眠微架构测量可以作为与OSA相关的认知障碍的有价值的生物标志物.
了解这些机制可以为OSA的认知功能障碍提供有针对性的治疗策略.

关键词:

认知认知认知调解调解是指调解的方式.阻塞性睡眠呼吸暂停 (SOP) 的情况.几率比率的产物是几率比率.睡眠微型架构睡眠微型架构螺丝,螺丝,螺丝,螺丝,螺丝,螺丝.

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