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Chuming Pang¹, Biao Li¹, Zishan Tu¹

¹Faculty of Materials Science and Engineering, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China.

ACS applied materials & interfaces

|June 29, 2024

概括

新的阴离子聚合物形成纳米聚合物,可以有效地消除金黄色葡萄球菌生物膜. 这些自组装的纳米聚合物克服了透问题,提供了对抗生物膜感染的有希望的策略.

科学领域:

材料科学材料科学材料科学
微生物学微生物学
聚合物化学聚合物化学

背景情况:

与生物膜相关的感染是全球主要的健康挑战.
传统的抗菌剂难以通过生物膜的细胞外聚合物物质矩阵透.
开发具有增强抗菌膜活性和透性的药物至关重要.

研究的目的:

开发具有强大的抗菌膜活性的新型自组装纳米聚合物.
为了研究基于玻利-瓜尼丁的酸性聚合物 (BGNx-n) 与黄金菌生物膜的结构-活性关系.
评估开发的纳米聚合物的透能力和安全概况.

主要方法:

基于玻利-瓜尼丁的两性阳性聚合物 (BGNx-n) 的合成.
自组装纳米聚合物的特征及其解离行为.
评估抗菌活性,最小抑制度 (MIC) 和抗菌膜对成熟的黄金色杆菌生物膜的有效性.
血液溶解的评估以确定细胞毒性.

主要成果:

BGNx-n聚合物自组装成具有局部正电荷的纳米聚合物,增强与负电荷的细菌和生物膜的相互作用.
在与生物膜接触时,纳米聚合物分解成较小的聚合物,改善透.
BGNx-n纳米聚合物表现出强大的抗菌活性,对黄金色斑马菌 (MIC为62.5μg·mL-1).
成熟的S. aureus生物膜在4 × MIC时被根除,血液溶解是可以忽略的.

结论:

大小可变的BGNx-n自组装系统为开发有效的抗菌膜剂提供了有前途的战略.
瓜尼丁部分增强了水友性和膜透性,这对抗菌膜有效性至关重要.
这些纳米聚合物代表了对抗具有挑战性的生物膜感染的新方法.

关键词:

(+) - 玻里诺醇可以生物膜是一种生物膜.瓜尼迪因 (guanidine) 是一种药物.自然产品是自然产品的产品.自动组装的自动组装机

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