相关实验视频
Updated: Jun 22, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
设计,合成和新型甲酸衍生物的杀虫剂/杀虫剂的活动,包括一个imide moiety
Dongdong Liu1,2, Jialin Ye1, Yixing Gao1
1Institute of Functional Molecules, Shenyang University of Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Shenyang 110142, China.
具有1 - cyclopropimide组的新型phenylpyrazole衍生物显示出强大的杀虫活性. 化合物A15对关键农业害虫特别有效,这表明有可能开发新型杀虫剂.
科学领域:
- 农业化学 农业化学
- 有机化学 有机化学
- 虫害管理 虫害管理 虫害管理
背景情况:
- 尼科夫卢作为开发新型杀虫剂的主要化合物.
- 甲衍生物是一种已知的杀虫剂类别,具有多样化的应用.
- 持续需要新的杀虫剂,提高有效性和向特异性.
研究的目的:
- 设计和合成新型的甲酸相似物.
- 评估合成化合物对关键农业害虫的杀虫活性.
- 阐明结构-活动关系和潜在的作用机制.
主要方法:
- 通过对胺酸进行乙基化,合成酸类相似物的化学合成.
- 生物测试以确定杀虫活性,包括针对特定害虫的LC50值.
- 分子对接模拟用于预测与目标受体的结合相互作用.
- 密度函数理论 (DFT) 计算来评估电子属性及其与活动的关系.
主要成果:
- 化合物A12-A17,其中包括1 - cyclopropimide部分,显示出显著的杀虫活性.
- 对抗Tetranychus cinnabarinus的A12-A17化合物的LC50值在0.58至0.91毫克/升之间.
- 化合物A15对Plutella xylostella (LC50=0.29毫克/升) 和Myzus persicae (LC50=3.10毫克/升) 具有强烈的活性.
- 分子对接表明A15化合物与氨酸 (GABA) 受体的潜在相互作用.
- DFT的计算表明,1-cyanocyclopropimide组对于生物活性至关重要.
结论:
- 含有1-cyanocyclopropimide片段的烯酸衍生物具有强大的杀虫性能.
- 化合物A15显示为开发针对特定害虫的新杀虫剂的领先化合物.
- 1-cyanocyclopropimide结构是本系列杀虫剂活性的关键药物.
- 对这些化合物的进一步研究和开发可能会导致有效的害虫防治解决方案.
相关概念视频
Preparation of Amides
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Diazonium Group Substitution: –OH and –H
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Aldehydes and Ketones with Amines: Imine Formation Mechanism
Imines are formed under mildly acidic conditions. A pH of 4.5 is ideal for the reaction.
If the pH is low or the solution is too acidic, the reaction slows down in the...
Aldehydes and Ketones with Amines: Imine and Enamine Formation Overview
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)