欧米茄-3多不和脂肪酸和脂肪组织炎症:PROMISE队列中的纵向分析
Ji-Eun Chon1, Zhila Semnani-Azad1,2, Kira Zhi Hua Lai1
1Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
The Journal of clinical endocrinology and metabolism
|June 29, 2024
概括
较高的欧米茄-3 (n-3) 多不和脂肪酸 (PUFA) 与人类脂肪组织炎症的减少有关. 这项研究表明,n-3PUFA可能有助于控制慢性炎症.
科学领域:
- 营养科学 营养科学
- 人体生理学 人体生理学
- 炎症研究 炎症研究
背景情况:
- 临床前研究表明,omega-3 (n-3) 多不和脂肪酸 (PUFA) 可以减少脂肪组织 (AT) 的炎症.
- 对n-3PUFA对AT炎症的影响的人类研究有限.
研究的目的:
- 调查循环中的n-3PUFA水平与人类AT炎症生物标志物之间的纵向关联.
- 提供关于n-3PUFA在控制AT炎症中的作用的证据.
主要方法:
- 使用了PROMISE队列 (n=474) 的纵向数据.
- 在基线和两次随访时通过循环生物标志物测量了AT炎症.
- 在基线的四个血清脂质分数中评估了n-3PUFA.
- 使用通用估计方程进行纵向关联分析,调整共变量.
主要成果:
- 较高的血清eicosapentaenoic acid,n-3 docosapentaenoic acid和docosahexaenoic acid与可溶性CD163 (P < .05) 的变化相反相关.
- 增加的n-3多可萨氨酸和多可萨氨酸与阿迪波内克丁的变化正相关 (P < .05).
- 对n-3PUFA与可溶性CD163和adiponectin的血清脂质分数之间发现了一致的关联.
结论:
- 这些发现有助于人类对n-3PUFA和AT炎症的有限证据.
- 表明n-3PUFA可能在预防和管理AT炎症方面发挥作用.
- 告知潜在的未来干预措施,针对脂肪组织的慢性炎症.
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