对酒精和大麻的指甲样本测试的敏感性,特异性和与自我报告的不一致性
Kristen P Morie1, Kathryn Gilstad-Hayden2, Steve Martino2
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Drug and alcohol dependence
|June 29, 2024
概括
对酒精 (乙基葡萄化物) 和大麻 (carboxy-delta-9-THC) 的指甲毒理学测试显示敏感度低,但特异性高. 指甲测试和自我报告之间的差异可能表明未被捕获的物质使用模式或报告的不准确性.
科学领域:
- 法医毒理学 法医毒理学
- 临床化学 临床化学
- 药物中毒药物 药物中毒药物
背景情况:
- 爪子可以储存几个月的酒精 (乙基葡萄化物) 和大麻 (carboxy-delta-9-THC) 代谢物.
- 很少有研究评估了指甲测试与自我报告的物质使用之间的准确性和一致性.
研究的目的:
- 评估指甲毒理学对检测酒精和大麻使用的敏感性和特异性.
- 检查指甲代谢物水平与自我报告的物质使用和相关危害之间的一致性.
- 为了确定与指甲测试结果和自我报告之间的差异相关的因素.
主要方法:
- 在一项临床试验中,1101名退伍军人提供了指甲切片进行分析.
- 将指甲代谢物水平 (ETG,carboxy-delta-9-THC) 与自我报告的酒精 (AUDIT-C) 和大麻使用 (ASSIST) 相比较.
- 统计分析发现了与指甲测试和自我报告之间不一致的因素.
主要成果:
- 指甲测试显示灵敏度低 (0.49-0.61),但用于检测酒精和大麻使用的特异性高 (>0.77).
- 疼痛,未婚,非西班牙裔种族,非裔美国人/西班牙裔种族和法律问题等因素与假阳性指甲测试有关.
- 返回剪指甲的受访者不成比例地已婚,白人,老年人和不太抑郁.
结论:
- 标准切断指甲毒理学揭示低灵敏度和高特异性检测酒精和大麻使用.
- 钉子测试和自我报告之间的差异可能暗示了被问卷遗漏的物质使用模式,不准确的自我报告或独特的药物代谢.
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