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在2型糖尿病患者的血清L C3-II水平与功能受损的患者

Shahab Ahmed Salıh Gezh¹, Koksal Deveci¹, Hakan Sivgin²

¹Tokat Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biochemistry, 60100, Tokat, Turkey.

|June 29, 2024

概括

在2型糖尿病 (T2DM) 患有功能障碍的患者中,血清LC3-II水平升高,可能表明受体细胞受损. 增加的LC3-II显示出作为监测糖尿病病进展的生物标志物的潜力.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
生物化学生物化学

背景情况:

糖尿病病 (DKD) 是2型糖尿病 (T2DM) 的一个主要并发症.
需要生物标志物来评估T2DM患者的功能障碍和细胞损伤.

研究的目的:

评估不同程度功能障碍的T2DM患者的LC3-II,BCL-2,IL-1β,TGF-β1和podocin的血清水平.
确定血清LC3-II作为DKD生物标志物的诊断潜力.

主要方法:

纳入了176名土耳其人 (150名T2DM患者,26名健康对照).
T2DM患者的分类是基于白蛋白尿和估计的淋巴球过率 (eGFR).
测量了LC3-II,BCL-2,IL-1β,TGF-β1和podocin的血清水平.这些血清含量包括:

主要成果:

在T2DM患者中,血清LC3-II水平显著增加,患有宏蛋白尿和功能受损.
在血清LC3-II和BCL-2,IL-1β,TGF-β1和podocin水平之间观察到强烈的相关性.
血清LC3-II显示了75.4%的效率在区分T2DM患者与大蛋白尿和那些与正常蛋白尿.

结论:

患有功能障碍的T2DM患者血清LC3-II升高可能与受细胞损伤有关.
血清LC3-II可以作为一种新的生物标志物,用于监测T2DM中损伤的发展和进展.

关键词:

自自是一种自的过程.在BCL-2中.DKD DKD DKD 的意思是什么在 LC3-II 中.波多西尼是一种葡萄酒.蛋白质尿症是一种蛋白质尿症.

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