边际状态,辅助治疗和口腔癌复发的情况
Sneha Kamalakkannan1, Firoz Rajan2, Jeevithan Shanmugam3
1Departments of Otolaryngology-Head and Neck Surgery, Kovai Medical Center and Hospital, Coimbatore 641014, India.
Oral oncology
|June 29, 2024
概括
手术边缘状态显著影响口腔癌复发. 涉及的边缘 (<1毫米) 预测更糟糕的结果,而密切的边缘 (1-4毫米) 可能允许辅助治疗降级,如果≥2毫米.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 头部和部癌症研究研究
背景情况:
- 口腔癌切除需要清晰的外科边缘,以防止复发.
- 不同边际状态的预后意义和辅助治疗的作用仍然是需要研究的领域.
研究的目的:
- 为了评估手术边缘在切除口腔癌的预后价值.
- 为了确定辅助治疗是否可以根据边际状态和其他风险因素量身定制.
主要方法:
- 分析了167名以前没有接受过治疗的口腔癌患者的队列.
- 边缘分为透明 (≥5毫米),接近 (1-4毫米) 或涉及 (<1毫米).
- 局部无复发生存率 (LRFS) 是主要结果,并对近边缘和辅助治疗接收进行亚组分析.
主要成果:
- 与明显 (89%) 和接近 (96%) 利率相比,涉及的利率与较差的三年LRFS (65%) 有很强的关联.
- 确定了2毫米的边缘切线,在此以上,LRFS接近了清晰边缘的边缘切线.
- 辅助治疗没有显著改变LRFS在临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床
结论:
- 口腔癌的近手术边缘与涉及边缘不同,并且有更好的预后.
- 口腔癌患者的边缘≥2毫米,没有其他不良特征可能是遗漏辅助治疗的候选人,改善治疗降级.
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