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-2-乙烯基) 酸盐通过KIF11-Wnt/β-catenin信号通路促进良性前列腺增生

Pan Song¹, Dong Lv², Luchen Yang¹

¹Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.

Ecotoxicology and environmental safety

|June 29, 2024

概括

暴露于二--2-乙烯甲酸盐 (DEHP) 通过激活KIF11/Wnt/β-catenin通路,促进良性前列腺增生 (BPH). 这涉及前列腺体重增加,细胞增殖和上皮质加厚,通过基因素乙化介导.

科学领域:

环境毒理学环境毒理学
分子生物学分子生物学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

-2-乙烯基) 甲酸盐 (DEHP) 广泛使用和生物积累,可能导致长期健康影响.
虽然DEHP暴露和良性前列腺增生 (BPH) 之间存在关联,但潜在的机制尚不清楚.

研究的目的:

研究DEHP暴露促进BPH的分子机制.

主要方法:

鼠被暴露于DEHP或其代谢物MEHP.
用MEHP治疗BPH-1细胞.
转录基因组测序在老鼠前列腺组织上进行.
进行了基因淘汰和分子通路分析 (Wnt/β-catenin,H3K27ac).

主要成果:

在大鼠中,DEHP/MEHP暴露增加了前列腺体重,前列腺指数和上皮质加厚.
MEHP促进了BPH-1细胞的增殖.
确定了KIF11作为一个由DEHP/MEHP调节的关键枢纽基因.
MEHP通过p-GSK-3β和β-catenin激活了Wnt/β-catenin通路.
基因素H3乙化 (H3K27ac) 介导KIF11上调.

结论:

通过H3K27ac调节的KIF11/Wnt/β-catenin信号通路,DEHP暴露会促进BPH.
在MEHP诱导的前列腺细胞增殖和途径激活中,KIF11起着至关重要的作用.

关键词:

良性前列腺增生症良性前列腺增生症 -2-乙烯基) 甲酸盐希斯 H3 氨酸 27 乙化 KIF11/Wnt/β-catenin的使用情况.

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