一个REM活跃的基底质回路,调节焦虑
Wei Ba1, Mathieu Nollet2, Chunyu Yin3
1Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Current biology : CB
|June 29, 2024
概括
研究人员确定了一种新型的大脑电路,该电路对于快速眼动 (REM) 睡眠至关重要. 这种涉及特定神经元的电路对于情绪弹性和稳定对压力的反应至关重要.
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
背景情况:
- 快速眼动 (REM) 睡眠与情绪弹性有关,但潜在的神经元机制尚不清楚.
- 识别调节REM睡眠的特定神经回路对于理解其功能至关重要.
研究的目的:
- 识别和描述负责产生和维持REM睡眠的神经回路.
- 研究由这些电路调节的REM睡眠在情绪弹性和应激反应中的作用.
主要方法:
- 在小鼠中利用化学遗传学来操纵脑内核 (EP) 和侧面大脑 (LHb) 中的神经元活动.
- 监测REM睡眠持续时间和在神经元抑制或激活后对厌恶刺激的行为反应.
- 研究了EP神经元激活对腹部体区域 (VTA) 的下游影响.
主要成果:
- 位于内细胞核 (EPSom) 的体静止素 (Som) 神经元在REM睡眠期间主要活跃,并且对其维持是必要和充分的.
- 激活EPSom神经元的目标是侧面布 (LHb) 中的Vglut2细胞,这反过来又通过腹膜区域 (VTA) 影响睡眠.
- 通过抑制LHb来实现的REM睡眠的慢性减少,导致小鼠对厌恶刺激的焦虑和敏感性增加.
结论:
- 已识别的EP → LHb → VTA电路在产生REM睡眠中起着关键作用.
- 由这个电路调节的累积REM睡眠,通过稳定对习惯性厌恶刺激的反应,有助于情绪弹性.
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