脂肪组织的胰岛素抵抗与儿童代谢功能障碍相关的脂肪性肝病的疾病严重程度相关:一项前性队列研究
Anneleen Heldens1, Ellen Dupont2, Lindsey Devisscher3
1Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium.
The Journal of pediatrics
|June 29, 2024
概括
脂肪组织的胰岛素耐药性 (Adipo-IR) 与儿科代谢功能障碍相关的脂肪性肝病 (MASLD) 有关. 在肥胖儿童中,生活方式干预改善了MASLD和Adipo-IR.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 肝病学 肝病学是一种肝病学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 儿童代谢功能障碍相关的脂肪性肝病 (MASLD) 是肥胖儿童日益关注的问题.
- 脂肪组织胰岛素耐药性 (Adipo-IR) 与代谢障碍有关,但其在儿科MASLD中的作用需要进一步阐明.
研究的目的:
- 调查Adipo-IR与儿科MASLD发展之间的关联.
- 在严重肥胖儿童的生活方式干预计划期间跟踪Adipo-IR的变化.
主要方法:
- 200名严重肥胖儿童和青少年的前性队列研究.
- 通过超声波和过渡性弹性图谱评估肝脏脂肪和纤维化.
- 在基线和随访期间 (4-6个月间隔) 测量Adipo-IR和肝脏胰岛素耐药性 (HOMA-IR).
主要成果:
- 56%的肥胖患者患有肥胖症,26%患有纤维化 (≥F2).
- 脂-IR水平随着肝病的严重程度逐渐增加,从瘦肉对照到有纤维化的MASLD.
- 改善的阿迪波-IR与减少的肝脂肪和氨酸酶水平相关;生活方式干预导致了MASLD和阿迪波-IR的改善.
结论:
- 阿迪波-IR与儿科MASLD的存在和严重程度显著相关,特别是肉脂症.
- 生活方式干预措施在改善小儿群体的Adipo-IR和MASLD方面表现有前途.
相关概念视频
Insulin: The Receptor and Signaling Pathways
1.2K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.2K
Diabetes: Symptoms, Diagnosis, and Complications
521
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
521
Obesity
447
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
447
Overview of Lipid Metabolism
1.4K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.4K
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Pathophysiology of Diabetes
918
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
918


