代谢功能障碍相关的脂肪肝疾病和动脉样硬化心血管疾病之间的关联
Wen Wen1, Hua Fan2, Shenghui Zhang3
1Department of Cardiology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, 313000, Zhejiang, China.
The American journal of the medical sciences
|June 29, 2024
概括
与脂肪肝疾病 (MAFLD) 相关的代谢功能障碍与动脉样硬化心血管疾病 (ASCVD) 有关. 本综述探讨了MAFLD-ASCVD的联系,考虑了新的定义和潜在的潜在机制.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个与代谢综合征,肥胖和2型糖尿病 (T2DM) 相关的全球健康问题.
- 越来越多地认识到NAFLD与动脉样硬化心血管疾病 (ASCVD) 有关,这在肝脏特异性并发症之外,对患者死亡率有显著的贡献.
- 2020年与脂肪肝疾病 (MAFLD) 相关的代谢功能障碍的出现,更新了标准,将其与NAFLD区分开来,尽管存在重叠.
研究的目的:
- 通过使用最近的定义和诊断标准,研究MAFLD和ASCVD之间的关系.
- 审查将MAFLD与心血管疾病发展联系在一起的潜在机制.
- 在代谢障碍和心血管风险的背景下,提供关于脂肪肝疾病的最新观点.
主要方法:
- 文献综述侧重于2020年MAFLD定义引入后发表的研究.
- 对区分MAFLD和NAFLD的诊断标准的分析.
- 综合关于MAFLD和ASCVD之间关联的证据,包括机械学的见解.
主要成果:
- MAFLD代表了与NAFLD不同的实体,更新的标准影响了患者群体的定义.
- 有证据表明,MAFLD与ASCVD风险增加之间存在强烈的关联.
- 了解链接代谢功能障碍,肝病和心血管并发症的病理生理学至关重要.
结论:
- MAFLD是ASCVD的重要风险因素,需要对受影响个体的心血管风险评估进行重新评估.
- 需要进一步的研究来阐明在MAFLD中介于心血管损伤的特定途径.
- 在MAFLD和NAFLD之间的区别可以改进临床管理和心血管并发症风险分层.
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