在患有症状甲状腺眼病的患者中,teprotumumab输注对眼睛对齐的影响
Charles Zhang1, Sinan Ersan2, Yousef Yousef2
1Department of Ophthalmology, Ross Eye Institute, University at Buffalo, Buffalo, New York.
概括
甲状腺眼病治疗teprotumumab显著减少了患者的眼睛错位和双眼视. 完整的治疗过程导致73%的视改善,46%的双眼视完全消失.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺眼部疾病 (TED) 引起位和眼部 misalignment,导致视力丧失.
- 新型IGF-1R抑制剂Teprotumumab于2020年被批准用于TED治疗.
- 眼部错位严重影响患者的生活质量.
研究的目的:
- 为了评估全疗程的teprotumumab在解决TED患者的眼睛 misalignment 的疗效.
- 评估teprotumumab对视和双眼视的影响.
- 确定影响治疗结果的因素.
主要方法:
- 对19名接受teprotumumab治疗的TED患者的回顾性审查 (2020年4月至2023年9月).
- 同时测试镜覆盖,用于每次访问的感觉运动检查.
- 对人口统计数据和先前治疗史 (放射性,类固醇,手术,吸烟) 的分析.
主要成果:
- 十一名患者出现了视和双眼视,最初的平均总失调为11.5Δ.
- 在治疗后,平均总失调减少了3.2Δ (P=0.04).
- 73%的患者表现出斜视的减少,46%报告说双眼视的消失;没有发现预测因素.
结论:
- 一个完整的teprotumumab疗程有效地减少了TED患者的眼睛 misalignment.
- 采用teprotumumab治疗导致视和双眼视的显著改善.
- 进一步的研究可能会探索治疗反应的预测标记.
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