微塑料对海微生物群和疾病易感性的潜在影响
Vitória Bonfim Iurk1, Mariana Ingles2, Giovana Sequinel Correa3
1Laboratório de Ecologia e Conservação, Centro de Estudos do Mar, Universidade Federal do Paraná, PR 832555-000, Brazil; Laboratório de Microbiologia Ambiental, Departamento de Biologia Estrutural, Molecular e Genética, Setor de Ciências Biológicas e da Saúde, Universidade Estadual de Ponta Grossa, PR 84030-000, Brazil.
The Science of the total environment
|June 29, 2024
概括
微塑料会损害海的肠道微生物组,破坏免疫功能,增加疾病风险. 像益生菌这样的干预措施可能有助于恢复肠道健康,并提高受影响的海的免疫力.
科学领域:
- 海洋生物学 海洋生物学
- 微生物组研究 微生物组研究
- 环境毒理学环境毒理学
背景情况:
- 微塑料 (MP) 是普遍存在的海洋污染物.
- 海吞食MPs,暴露了它们的肠道微生物群.
- 暴露于MP可以引起肠道失生症并增加疾病易感性.
研究的目的:
- 审查MP暴露对海肠道微生物群的影响.
- 探索MP暴露与海疾病之间的联系.
- 总结有关MP对海洋动物健康的影响的当前知识.
主要方法:
- 关于微塑料和海肠道健康现有研究的文献综述.
- 分析与肠道微生物组功能相关的代谢和遗传数据.
- 探索疾病联系和潜在的治疗干预措施.
主要成果:
- MPs破坏肠道微生物组的平衡,改变了必需代谢物 (如SCFA) 的产生.
- 改变的肠道微生物组会影响宿主基因表达,影响肠道完整性和免疫力.
- 暴露于MP会增加对机会性病原体的易感性,例如与纤维细胞瘤 (FP) 相关的CHAHV5.
结论:
- 国会议员破坏肠道微生物组,危及海的免疫系统.
- 这种脆弱性可能会导致对FP等疾病的易感性增加.
- 饮食干预和益生菌对恢复海的肠道健康和免疫功能充满希望.
相关概念视频
Marine Microbial Ecology
Marine microbial ecosystems are shaped by distinct physicochemical limits, including high salinity, low nutrient availability, and fluctuating oxygen levels. These conditions favor smaller microbial cell sizes, which maximize their surface-to-volume ratio for efficient nutrient uptake.Microbial activity and community composition are closely linked to biogeochemical cycles, particularly in dynamic environments like estuaries, where halotolerant microbes thrive in response to variable salinity...
Introduction to the Human Microbiota
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Microbial Bioremediation of Plastics
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


