听力皮层的功能连接在与创伤相关疾病的女性中,她们听到声音
Meiling Li1, Lauren A M Lebois2, Caitlin Ridgewell3
1Division of Brain Sciences, Changping Laboratory, Beijing, China.
概括
在创伤幸存者的声音听觉 (VH) 与大脑连接的改变有关. 具体来说,左侧上旋显示了与参与自我引用和执行功能的网络不同的功能连接 (FC).
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 创伤研究 创伤研究
背景情况:
- 声音听觉 (VH) 是创伤相关疾病中常见的症状,但其神经基础不明.
- 听觉感知功能障碍与精神分裂症中的VH有关,但其在创伤相关的VH中的作用尚不清楚.
研究的目的:
- 在患有创伤相关疾病和不同严重程度的VH的女性中调查与听觉皮层 (AC) 相关的功能连接 (FC).
- 探索大脑和小脑内VH严重程度和FC之间的关联.
主要方法:
- 使用功能性大脑分片来计算初级 (Heschl's gyrus) 和非初级 (侧上旋) AC亚区域的FC.
- 检查了FC与大脑和小脑网络.
- 使用交叉验证和回归分析,与FC相关的VH严重程度.
主要成果:
- VH严重程度与左侧上时回形-前对称网络FC正相关.
- VH严重程度与左侧上时线FC与大脑和小脑的默认模式网络区域负相关.
- 左的Heschl's gyrus或右AC亚区域的FC没有预测VH严重程度.
结论:
- 研究结果表明,在创伤相关的VH中,听觉感知和自我参考/执行网络之间的相互作用发生了变化.
- 这是第一个在创伤相关的VH中证明听力皮层连接性改变的研究.
- 与创伤相关的VH可能涉及与精神分裂症相关的VH相比不同的神经机制,尽管共享网络参与.
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