血清总胆固醇和血压之间的关联在组合口服避孕药使用者的血压
T Sharmin1, A Nessa, M A R Ferdous
1Dr Tania Sharmin, Lecturer, Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh;
Mymensingh medical journal : MMJ
|June 30, 2024
概括
联合口服避孕药 (COCs) 与血清总胆固醇和血压的增加有关. 这项研究发现COC,胆固醇水平和使用者的血压之间存在显著的积极关联.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
背景情况:
- 口服避孕药 (OCP) 在全球范围内广泛用于避孕,组合激素避孕药 (COC) 是最常见的类型.
- COCs含有雌激素和孕激素,提供高效率 (99.9%的理论,97-98%的典型使用).
- COCs的潜在代谢副作用需要进行调查,特别是关于心血管风险因素.
研究的目的:
- 为了研究血清总胆固醇水平和血压在使用组合口服避孕药的用户之间的关系.
- 为了比较使用COC的女性和年龄相匹配的非使用者之间的这些参数.
主要方法:
- 一项涉及120名孟加拉国生育年龄女性 (15-55岁) 的横截面研究.
- 参与者被分为两组:60名口服避孕药联合使用者 (II组) 和60名非使用者 (I组).
- 测量了血清总胆固醇,静脉血压和静脉血压;使用未配对的t测试和Pearson的相关系数分析数据.
主要成果:
- 在COC使用者 (p<0.001) 中,观察到血清总胆固醇与静缩血压 (r=0.582) 和静缩血压 (r=0.416) 之间存在统计学上显著的正相关性.
- 血压和血清总胆固醇在研究组 (COC用户) 与对照组相比被发现是正相关的.
- 这些发现表明,口服避孕药使用,胆固醇升高和血压升高之间存在显著的关联.
结论:
- 联合口服避孕药的使用与血清总胆固醇的显著增加有关.
- 联合口服避孕药使用和血压升高之间存在显著的积极关联.
- 这些发现表明,使用COC的女性可能由于脂质配置和血压的改变而增加患心血管问题的风险.
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