多发性骨髓瘤患者的临床病理概况在第三级护理医院
1Dr Md Mahbubul Alam, Junior Consultant (Medicine), Sheikh Russel National Gastroliver Institute and Hospital, Mohakhali, Dhaka, Bangladesh;
Mymensingh medical journal : MMJ
|June 30, 2024
概括
这项研究揭示了孟加拉国多发性骨髓瘤 (MM) 的共同特征,强调骨疼痛作为主要症状,以及贫血和功能障碍作为关键发现. 国际分期系统 (ISS) 阶段显示与血清肌素和水平有关.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 多发性骨髓瘤 (MM) 是一种成熟的B细胞瘤,其特征是血细胞的异常增殖和M蛋白.
- 了解MM的表现特征和实验室发现对于及时诊断和管理至关重要.
研究的目的:
- 描述呈现的特征,实验室发现,东部合作瘤组 (ECOG) 绩效状况,以及多发性骨髓瘤患者的骨调查结果.
- 在MM患者中确定临床和实验室参数之间的关联.
主要方法:
- 对81名多发性骨髓瘤患者进行了一项描述性的横截面研究.
- 收集了人口统计,临床表现,并发症,ECOG状态,实验室结果 (Hb,ESR,肌素,LDH,,白蛋白,β2-微球蛋白,BJP),骨调查和血细胞百分比的数据.
- 使用SPSS进行统计分析,在p<0.05.05时评估显著性.
主要成果:
- 患者的平均年龄为58.9岁,男性与女性的比例为2:1.
- 骨头疼痛 (72.8%) 是最常见的表现特征. 常见的并发病包括高血压 (59.1%) 和糖尿病 (29.5%).
- 在血清肌素和Hb度,ISS分期和血清水平之间发现了显著的关联. 在75.0%的患者中存在炎症性骨病变.
结论:
- 骨头疼痛,贫血,功能障碍和骨炎事件在多发性骨髓瘤患者中很突出.
- 国际分期系统 (ISS) 的分期在统计学上与血清肌素和血清水平有关,而这些水平又与病变有关.
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