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维生素D受体基因多态 (Fok 1),维生素D状态和自身免疫性甲状腺炎之间的关联
M Sinharay1, A Dasgupta, A Karmakar
1Dr Manali Sinharay, Associate Professor, Department of Biochemistry, Calcutta National Medical College, Kolkata, West Bengal, India;
维生素D受体基因中的FokI (rs2228570) 多态性与自身免疫性甲状腺炎有关. FF基因型与增加对这种疾病和维生素D缺乏的敏感性有关.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性甲状腺炎可能导致甲状腺功能低下和乳头甲状腺癌.
- 维生素D缺乏与自身免疫性疾病的发展有关.
- 维生素D受体基因多态性与自身免疫性疾病有关.
研究的目的:
- 调查维生素D受体基因FokI (rs2228570) 多态和自身免疫性甲状腺炎之间的关联.
- 探索这种多态性,维生素D水平和抗甲状腺抗体之间的关系.
主要方法:
- 一项基于医院的,非干预性的,横截面研究,涉及48名成年病例和50名健康对照.
- 使用烯甲方法进行DNA分离.
- 通过PCR和限制消化对FokI (rs2228570) 多态的分析.
- 使用千平方,赔率比和后期ANOVA进行统计分析.
主要成果:
- 维生素D受体基因FokI (rs2228570) 的FF基因型在自身免疫甲状腺炎组 (p=0.006) 中明显更为普遍.
- 在病例组 (p<0.001) 中,F等位基因显示出明显更高的几率比率 (p<0.001).
- 与其他基因型相比,具有FF基因型的个体具有显著较低的维生素D水平 (p=0.008) 和较高的抗TPO抗体水平 (p=0.031).
结论:
- 在维生素D受体基因FokI (rs2228570) 多态和自身免疫性甲状腺炎之间存在显著的关联.
- 在研究的东印度人群中,FF基因型是自身免疫性甲状腺炎和维生素D缺乏症的强烈易感因素.
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