父亲的炎症性肠病和怀孕损失的风险
Sonia Friedman1,2,3, Caroline Thingholm Thorarinsson2,3, Mette Wod2,3
1Gastroenterology Division, Tufts Medical Center, Tufts University School of Medicine, Boston Massachusetts, USA.
Inflammatory bowel diseases
|June 30, 2024
概括
检查了包括克罗恩病和性结肠炎在内的父性炎症性肠病对辅助生殖结果的影响. 患有克罗恩病的男性可能面临更高的早期怀孕流产风险,这需要进一步调查与疾病相关的因素.
科学领域:
- 生殖医学 生殖医学
- 胃肠病学 胃肠病学
- 不孕研究 不孕研究 不孕研究
背景情况:
- 关于导致流产的父亲因素的数据有限.
- 患有炎症性肠病 (IBD) 的男性可能会遇到生育挑战.
- 这项研究调查了在被诊断患有IBD的男性伴侣的辅助生殖中怀孕结果.
研究的目的:
- 评估父亲克罗恩病或性结肠炎与辅助生殖结果之间的关联.
- 为了确定与父亲IBD相关的怀孕流产的潜在风险.
主要方法:
- 使用丹麦辅助生殖注册 (2006-2019) 的全国性研究.
- 包括男性伴侣患有克罗恩病或性结肠炎 (暴露队列) 的胚胎移植.
- 与男性伴侣没有IBD (未暴露队列) 的胚胎移植进行比较.
主要成果:
- 性结肠炎的父亲在生化怀孕,临床怀孕或活产率方面没有显著差异.
- 克罗恩病的父亲在临床怀孕中具有统计学上显著的较低几率比率 (0.58).
- 在克罗恩氏病的父亲中,没有观察到生化妊娠或活产率的显著差异.
结论:
- 患有克罗恩病的男性的伴侣可能有较高的风险早期流产.
- 需要进一步的研究来证实这些发现.
- 调查父亲药物,疾病活动和其他IBD相关因素对怀孕结果的影响.
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