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针对炎症性肠道疾病的紧急腹部手术的紧急调整结果
J A Bunce1, J N Lund2, G M Tierney2
1Faculty of Medicine, Division of Health Sciences and Graduate Entry Medicine, Department of Colorectal Surgery, University of Nottingham at Derby, Royal Derby Hospital, Clinical Research Fellow, Royal Derby Hospital, Derby, UK.
炎症性肠病 (IBD) 患者的紧急手术显示出不同的结果. 风险评估和管理必须考虑到克罗恩病和性结肠炎患者的患者指标和生理状态的差异.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 临床流行病学临床流行病学
背景情况:
- 炎症性肠病 (IBD) 的紧急腹部手术是复杂的,在文献中代表性不足.
- 在IBD手术中定义"紧急情况"缺乏共识,使风险评估复杂化.
- 最近的工作重点是定义临床紧急情况和高风险的手术患者.
研究的目的:
- 分析患者的指标和风险在紧急IBD手术使用国家紧急 laparotomy审计 (NELA) 数据.
- 根据手术紧急情况,比较患者的特征,生理学,生物化学和结果.
- 为了确定克罗恩病 (CD) 和性结肠炎 (UC) 患者的风险概况的差异.
主要方法:
- 利用了NELA数据库 (2013-2016) 完整的患者数据,包括组织学.
- 分类的手术紧急情况为<2h,2-6h,6-18h和>18h.
- 采用回归分析来比较患者指标和紧急情况类别的结果.
主要成果:
- 在CD中死亡率在1.4% (>18h) 到14.6% (最紧急) 之间.
- 在UC的死亡率从3.1% (>18h) 到14.8% (最紧急).
- 对CD和UC的血液动力学不稳定性,白细胞数量,电解质,肌素,停留时间和返回剧院的显著趋势.
结论:
- 紧急IBD手术患者在生理学,生物化学或结果方面不是一个均的群体.
- 风险咨询和管理策略需要基于患者特定因素的个性化.
- 在这种队列中,细微的血液动力学变化可能会被忽视,需要仔细监测.
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