肝细胞维生素D受体作为营养传感器,调节斑马鱼的能量储存和组织生长
Scott H Freeburg1, Arkadi Shwartz1, Lajos V Kemény2
1Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cell reports
|June 30, 2024
概括
维生素D受体 (VDR) 通过调节营养储存和组织生长来协调能量平衡. 肝细胞中VDR信号的损失会损害能量使用和适应营养的可用性.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 进化生物学 进化生物学
背景情况:
- 维生素D受体 (VDR) 与脂肪肝疾病有关.
- 它在调节生物体能量消耗方面的作用尚未完全理解.
研究的目的:
- 研究VDR在能量恒温中的进化功能.
- 确定肝细胞中的VDR如何影响营养储存,组织生长和能量使用.
主要方法:
- 斑马鱼模型具有肝细胞特异性VDR损伤.
- 分析肝脏脂质储存,脂肪酸氧化和肝脏生长.
- 在不同的营养条件下评估全身生长和脂肪沉积.
主要成果:
- 肝细胞中VDR受损增加了肝脂储存和acsl4a表达.
- 观察到脂肪酸氧化和肝脏生长的减少与VDR损伤.
- 丧失VDR信号加剧了饥饿引起的肝脂肪酸储存和饮食引起的全身生长减弱.
- 肝细胞VDR受损导致内脏脂肪增加,尽管整体生长减少.
结论:
- 肝细胞VDR对于协调肝脏和生物体的能量恒温至关重要.
- VDR信号调节营养储存和组织生长,以应对环境营养供应.
- VDR作为一个转录效应因子,将营养素的可用性与能量消耗和适应性联系起来.
关键词:
CP:新陈代谢过程中的新陈代谢.进化 演化 演化 演化 演化 演化 演化 演化肝脏 肝脏 肝脏 肝脏 肝脏 肝脏代谢 代谢 代谢 代谢核激素受体 核激素受体维生素D是维生素D的重要组成部分.斑马鱼是一种斑马鱼.更多相关视频
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