肠道微生物群介导的多醇代谢受到寄生虫鞭虫感染的抑制,并与小鼠的免疫功能改变有关
Audrey Inge Schytz Andersen-Civil1, Pankaj Arora1, Ling Zhu1
1Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Gut microbes
|June 30, 2024
概括
普罗安托西亚尼丁 (PAC) 聚醇对肠道寄生虫和免疫反应产生影响. 然而,寄生虫感染可以减少PAC.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 营养 营养 营养 营养 营养
背景情况:
- 在植物性饮食中丰富的多,具有免疫调节和抗炎性质.
- 饮食中的多,肠道病原体和粘膜表面的主体免疫之间的相互作用仍然不完全理解.
研究的目的:
- 在小鼠的寄生虫感染期间,研究氨素 (PAC) 聚醇对宿主免疫反应和肠道微生物代谢物的影响.
- 阐明PAC,肠道寄生虫 (Heligmosomoides polygyrus和Trichuris muris) 与宿主的免疫系统和微生物群之间的相互作用.
主要方法:
- 给小鼠注射了PAC,并感染了H. polygyrus或T. muris.
- 分析了母细胞反应,宿主组织转录组,肠道微生物群组成和便代谢物.
- 研究了与炎症和宿主防御相关的基因表达途径.
主要成果:
- 在H. polygyrus感染期间,PAC的摄入抑制了巨细胞形成,并在T. muris感染期间增强了1型炎症通路.
- 在未感染的小鼠中,PAC增加了Turicibacter的丰富性,便短链脂肪酸和便的类代谢物.
- T. muris感染减少了PAC对肠道微生物群和代谢物的有益作用,表明PAC的代谢功能受损.
结论:
- PAC与肠道寄生虫相互作用,影响宿主免疫反应,并可能增加寄生虫诱导的炎症.
- 寄生虫感染可以减弱PAC的有益的肠道微生物介导作用,突出显示了复杂的植物营养素-病原体-宿主关系.
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