牙损失是心血管疾病死亡的危险因素:通过元分析进行系统审查
Anita Aminoshariae1, Ali Nosrat2, Aleksandar Jakovljevic3
1Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio.
Journal of endodontics
|June 30, 2024
概括
失去所有的牙 (没有牙) 或少于10颗牙显著增加心血管疾病 (CVD) 死亡的风险. 这一系统性审查证实牙损失是心血管疾病死亡风险的关键指标.
科学领域:
- 口腔健康 口腔健康
- 心血管疾病流行病学
- 系统性审查和元分析.
背景情况:
- 牙脱落和心血管疾病 (CVD) 死亡率之间的联系仍然不清楚.
- 现有证据是不确定的,需要进一步调查.
研究的目的:
- 系统地审查和分析牙脱落与心血管疾病死亡率之间的关联.
- 提供当前证据的全面概述.
主要方法:
- 在多个数据库和灰色文献来源中进行了系统的文献搜索.
- 包括集中在心血管疾病死亡率和牙损失的研究,使用纽卡斯尔-太华尺度进行评估.
- 进行了随机效应元分析,子组分析,元回归和灵敏度分析.
主要成果:
- 包括12篇高质量的文章,揭示了牙损失 (无牙或<10颗牙) 与心血管疾病死亡率 (HR=1.66) 之间的显著关联.
- 亚组分析表明,没有牙的个体在没有显著异质性的情况下具有更高的风险,而牙小于10颗的个体在具有显著异质性的情况下具有更高的风险.
- 敏感性分析证实牙损失是心血管疾病死亡的风险因素 (HR=1.52).
结论:
- 失去牙,特别是没有牙或牙少于10颗,是心血管疾病死亡率的重要预测因素.
- 这些发现强调了口腔健康对心血管健康结果的重要性.
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