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Updated: Jun 22, 2025

Author Spotlight: Decoding Mitochondrial Aging
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在晚年抑郁症中与外基因组相关的线粒体DNA:对老年人认知能力下降的影响

Ana Paula Mendes-Silva1, Yuliya S Nikolova2, Tarek K Rajji3

  • 1Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada.

Journal of affective disorders
|June 30, 2024
PubMed
概括

外体的线粒体DNA (EX-mtDNA) 完整性,而不是水平,与晚年抑郁症 (LLD) 的认知衰退相关. 在LLD中更高的EX-mtDNA删除率表明它有可能作为认知结果的生物标志物.

关键词:
认知功能 认知功能外基因组是外基因组的组成部分.炎症 炎症是一种炎症.晚年生活中的抑郁症.线粒体DNA是线粒体的DNA.

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