五个东南亚国家的骨周转标记参考数据库
Joon Kiong Lee1, Hui Min Khor2, Pojchong Chotiyarnwong3
1Department of Orthopedic Surgery, Beacon Hospital, Petaling Jaya, Selangor, Malaysia.
Bone
|June 30, 2024
概括
这项研究确定了东南亚绝经前妇女骨循环标记 (BTM) 的第一个参考范围. 这些发现对于该地区精确的骨质疏松症评估和管理至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 人口健康 人口健康
背景情况:
- 骨质疏松症的患病率很高,特别是在发展中国家.
- 亚洲人群缺乏已确立的骨周转标记 (BTM) 参考范围.
- 准确的BTM对于骨质疏松症的诊断和监测至关重要.
研究的目的:
- 为五个东盟国家开发一个区域BTM参考数据库.
- 为了确定血清Procollagen 1 N-终端 Propeptide (P1NP),骨素 (OC) 和Beta-Crosslaps (CTX) 的参考间隔.
- 为东南亚骨质疏松症管理提供基础.
主要方法:
- 来自马来西亚,菲律宾,新加坡,泰国和越南的综合国家具体数据.
- 分析了746名年龄在20-44岁之间的健康的绝经前妇女.
- 使用自动化免疫检测系统测量P1NP,OC和CTX.
主要成果:
- 已建立的参考间隔:CTX (128-811 ng/L),OC (9.0-33.0 μg/L),P1NP (22.8-96.5 μg/L). 它们可以分为两种.
- 不包括20岁以下的人:CTX (117-678 ng/L),P1NP (21.6-85.8 μg/L),OC (3.5-27.0 μg/L).
- 观察到国家间的变化和30岁以后随着年龄的增长而减少的BTM.
结论:
- 这项研究为健康的绝经前东南亚妇女提供了第一个BTM参考间隔.
- 这些间隔对于准确评估该地区的骨周转率至关重要.
- 有助于改善骨质疏松症评估和患者监测.
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