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异位扩散大B细胞淋巴瘤呈现广泛的器官参与
Kailyn Kim1, Sharvina Ziyeh2, Phyllis Kim3
1Department of Medicine, UCLA Medical Center Olive View, Sylmar, California, USA.
BMJ case reports
|June 30, 2024
概括
淋巴结外的疾病 - - 淋巴结外的疾病 - - 在扩散性大B细胞淋巴瘤 (DLBCL) 中是罕见的. 这一案例突出了广泛的多器官DLBCL,强调了其扩散转移的潜力.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 病理学 病理学 病理学
背景情况:
- 在扩散性大B细胞淋巴瘤 (DLBCL) 中,多达三分之一的患者出现了外节参与.
- 在DLBCL中,多器官外节参与被认为是罕见的.
研究的目的:
- 描述一个罕见的广泛转移DLBCL的罕见病例,涉及广泛的 extranodal.
- 突出外性DLBCL的诊断和预后影响.
主要方法:
- 一个患有广泛的 extranodal DLBCL 的病人的病例报告.
- 审查乳腺病理学和成像发现.
- 讨论预后因素和新兴疗法.
主要成果:
- 患者呈现出广泛转移的病变,涉及肺部,腺,乳腺,胰腺,大腿骨和软组织.
- 病理学证实IV期高度B细胞淋巴瘤,具有三倍表达体,双击特征和广泛的外节参与.
- 外节干涉被确定为预后不良的因素.
结论:
- 异位DLBCL可以呈现为广泛转移的疾病,涉及多个器官系统.
- 考虑 extranodal DLBCL对于恶性瘤的新呈现至关重要.
- 针对CD19的新疗法正在研究复发/耐药DLBCL.
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